The Malaria Research Centre (MRC) was established as one of the two Centres of Excellence by UNIMAS in January 2006. This was in recognition of the major contributions to malaria research by Prof Balbir Singh, Prof Janet Cox-Singh and co-researchers at the Malaria Research Laboratory, Faculty of Medicine and Health Sciences. These two scientists joined UNIMAS in 1999 to establish laboratory-based research in the new Medical Faculty and with financial support from UNIMAS, they were instrumental in designing and equipping state-of-the-art research laboratories. The acquisition of research grants from Wellcome Trust, United Kingdom, the Malaysian Ministry of Science, Technology and the Environment and UNIMAS, enabled them to train young scientists and establish an active group of researchers working on malaria.

The first of its kind in Sarawak and Malaysia, the Gamification Centre was launched on 1st August 2020, marking an exciting new beginning for its existing CreativeCulture initiatives and programmes. The centre focuses on developing research and developments in the field of Gamification of Learning, to advance thinking and competence. The Gamification Centre is located at the Faculty of Computer Science and Information Technology, UNIMAS. The research lab is called MyCapsule Space, as it is uniquely designed to promote creative innovation and collaborative work, exploratory play and open learning - a rethinking space that challenges 21st century learning.

The UNIMAS Data Science Center was established on the 10th of March 2022. The center aims to be a leading center that creates research impact for a sustainable future by advancing in core Data Science areas. In fulfilling this goal, the center set as her mission to transform data science solutions into generic workbench through continuous collaboration between data scientists and domain experts; and to educate new generations of data-aware professionals through technology transfer and consultation services.